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KMID : 0438520110180020365
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Journal of the Korean Society of Neonatology
2011 Volume.18 No. 2 p.365 ~ p.369
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Successful Opening of Ductus Arteriosus with Milrinone in a Newborn with Tetralogy of Fallot and Pulmonary Atresia
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Won Chong-Bock
Kim Min-Young
Choi Duk-Young
Shim So-Yeon
Cho Hye-Jung
Son Dong-Woo
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Abstract
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Tetralogy of Fallot (TOF) assumes its’ most severe form when accompanied by pulmonary atresia (PA). Preserving the patent ductus arteriosus to maintain pulmonary blood flow is life-saving for patients with this congenital heart disease. Milrinone, a selective phosphodiesterase III inhibitor, is a potent vasodilator. Here, we report the successful use of milrinone for a newborn infant with TOF and PA for keeping the ductus arteriosus open and thereby maintaining pulmonary circulation. Milrinone is a useful drug because of its inotropic, lusitropic, and pulmonary vasodilating effects, in addition to its ability to keep the ductus arteriosus open and its relatively mild side-effects. Case series and comparative studies will be needed in the future to verify the effectiveness of this drug.
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KEYWORD
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Congenital heart disease, Tetralogy of Fallot, Pulmonary atresia, Ductus arteriosus, Milrinone, Phosphodiesterase inhibitor, Newborn
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